Both players sat out the penultimate pre-season friendly, as the Reds drew 3-3 in Norway against Valarenga – conceding at least three goals for the fifth game in a row.
Portuguese star Meireles is currently sidelined with a foot problem, but it’s believed that the injury is just bruising and the former Porto man should be fit for the opening weekend.
Meanwhile, Skrtel, who played every minute of every Premier League game last season, is struggling with a calf injury and is more of a concern for Kenny Dalglish.
Pepe Reina got through his first game since a double hernia operation unscathed and the Spanish international is expected to feature again on Saturday, in the final friendly against Valencia.
St Mirren boss Jack Ross has told his Buddies he wants to see a sprint finish as they look to romp towards the Ladbrokes Championship flag.