City coach Pep Guardiola once again had to discuss another Kompany injury in midweek after the Belgian suffered knee ligament damage.
The Belgian will now spend another six weeks on the sidelines and his future at the Etihad Stadium is in doubt after 18 months of constant issues.
Guardiola is said to be in the market for another defender in January and reports suggest Van Dijk is his main target.
The former Celtic man is comfortable on the ball and both Liverpool and Manchester United have shown an interest in recent weeks.
Van Dijk signed a five year-deal when he joined the Saints in 2015 but Guardiola will be hoping that the lure of Champions League football could help him during negotiations.
Antonio Conte took the opportunity to compliment a rare talent after Lionel Messi masterminded Barcelona's Champions League defeat of Chelsea.
Wigan boss Paul Cook is happy to be heading into their FA Cup quarter-final with Southampton on the back of a morale-boosting league win.
Arsene Wenger has called on his Arsenal side to put on the sort of displays that will have stay-away fans returning to the Emirates Stadium.
Michael Jacobs struck in stoppage time as Wigan got their League One promotion bid back on track with a 1-0 win at Bradford.
Lionel Messi punished error-prone Chelsea as Barcelona advanced to the Champions League quarter-finals with a 3-0 win at the Nou Camp.
AC Milan boss Gennaro Gattuso believes Jack Wilshere would grace any league in world football.