The City captain is yet to feature in 2018 due to a calf problem and manager Pep Guardiola has confirmed he remains a doubt.
Gabriel Jesus went to Barcelona for a check on his knee injury this week and Guardiola, who remains without Benjamin Mendy (knee) and Phil Foden (ankle), anticipates having his Brazilian striker back training in two to three weeks.
Provisional squad: Bravo, Ederson, Walker, Danilo, Kompany, Stones, Otamendi, Mangala, Delph, Zinchenko, Toure, Gundogan, Fernandinho, Diaz, Sterling, Sane, D Silva, B Silva, De Bruyne, Aguero.
Colchester will hand late fitness tests to Ryan Jackson and Brandon Comley prior to their clash with Yeovil.
Arsenal secured their place in the quarter-finals of the Europa League following their 3-1 defeat of AC Milan at the Emirates Stadium on Thursday.