Rooney and Carrick missed Thursday’s Europa League tie against St Etienne with minor muscular injuries, with Mkhitaryan absent from the last-32 first-leg game through illness.
Centre-back Phil Jones will be hoping to return from a foot injury in time to face his former club, while Luke Shaw is pushing for a chance after being overlooked for United’s previous four squads.
Provisional squad: De Gea, Romero, Henderson, Darmian, Fosu-Mensah, Valencia, Young, Rojo, Jones, Tuanzebe, Smalling, Bailly, Blind, Shaw, Mata, Fellaini, Schweinsteiger, Herrera, Pogba, Lingard, Martial, Mkhitaryan, Rashford, Ibrahimovic.
Pedro stepped off the bench to send Chelsea into the FA Cup semi-finals after they beat Leicester 2-1 at the King Power Stadium on Sunday evening.
RB Leipzig came from behind at the Red Bull Arena to end a run of four winless games and defeat Bundesliga leaders Bayern Munich 2-1 on Sunday.