Nani has been sidelined since the start of November with a hamstring injury and boss Sir Alex Ferguson has revealed the Portugal international should be available again in four or five weeks.
Valencia has a hip injury and will miss Saturday’s fixture with the Royals.
Ryan Giggs could be recalled after recovering from a hamstring problem, while fellow veteran Paul Scholes is available following suspension.
Saturday’s game comes too soon for defender Nemanja Vidic but Ferguson has confirmed the Serbian may feature against CFR Cluj in the Champions League on Wednesday.
Domenic Tedesco says Schalke paid the price for missed chances as they were held to a 2-2 draw against Cologne on Sunday.
Jan Oblak says he is happy with Atletico Madrid but refused to completely rule out a move away from the club.
Harry Kane has conceded Tottenham players may have to adopt a fresh approach to big games after another semi-final defeat.
Arsene Wenger has hinted that growing supporter unrest influenced his decision to quit Arsenal at the end of the season.
Swansea boss Carlos Carvalhal says his side's hopes of beating the drop will not suffer following the 5-0 defeat at Manchester City.
Liverpool defender Virgil van Dijk says they are well aware of the threat that Roma possess as a whole, not just Edin Dzeko.
Antonio Conte says his row with Jose Mourinho is a thing of the past as they prepare to face off again in the FA Cup Final.
Paul Lambert believes Stoke will have to win their last three games to have any chance of staying in the Premier League.
Romelu Lukaku believes the current Manchester United squad can win the Premier League title next season saying quality is not an issue.