The 25-year-old Ivory Coast international, who moved to the French Ligue 1 side from Portuguese outfit Pacos de Ferreira in 2015, has enjoyed an impressive season with six goals and nine assists to help Nice up to third in the league under the guidance of coach Lucien Favre.
Reports claim Saints boss Claude Puel is keen to raid his former club and take Seri to St Mary’s in the summer, where the pair would be reunited having spent last season together with the French outfit.
The main obstacle is that a host of top clubs around Europe have been alerted by Seri’s good form this season and will almost certainly look to secure his signature in the transfer window.
In addition to the Saints, Premier League rivals Leicester and German outfit Borussia Dortmund have also been mentioned as potential suitors.
Nice are believed to be looking to pick up 40 million euros for Seri which could prove to be prohibitive for the Saints.
Colchester will hand late fitness tests to Ryan Jackson and Brandon Comley prior to their clash with Yeovil.
Arsenal secured their place in the quarter-finals of the Europa League following their 3-1 defeat of AC Milan at the Emirates Stadium on Thursday.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Ipswich striker Joe Garner will not play again this season after it emerged he suffered a fractured skull against Sheffield United last week.