Saints are in the market for a new centre-half following Virgil van Dijk’s move to Liverpool and Switzerland international Akanji has now emerged as a target.
Borussia Dortmund had seemed set to land the 22-year-old for a 30million euros fee in the winter window but the latest speculation in Germany claims their interest has cooled, with Dortmund prepared to wait until the summer before reigniting their bid.
That could allow Southampton the chance to move in and seal a deal but they could still face competition for Akanji.
Liverpool are also understood to be keen, despite their capture of Van Dijk, and a host of other clubs from across Europe have been linked with the defender.
Colchester will hand late fitness tests to Ryan Jackson and Brandon Comley prior to their clash with Yeovil.
Arsenal secured their place in the quarter-finals of the Europa League following their 3-1 defeat of AC Milan at the Emirates Stadium on Thursday.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Ipswich striker Joe Garner will not play again this season after it emerged he suffered a fractured skull against Sheffield United last week.