The former West Ham centre-back only joined the Potters last week but with fellow new signing Jonathan Woodgate to be rested the England international is set to play.
Winger Matt Etherington will play no part after injuring his shoulder against Chelsea at the weekend while Rory Delap (hamstring) and Jermaine Pennant (thigh) may also not be risked as manager Tony Pulis makes changes.
Colchester will hand late fitness tests to Ryan Jackson and Brandon Comley prior to their clash with Yeovil.
Arsenal secured their place in the quarter-finals of the Europa League following their 3-1 defeat of AC Milan at the Emirates Stadium on Thursday.
Danny Welbeck scored twice against AC Milan to toast his England recall by sending Arsenal into the last eight of the Europa League.
Ipswich striker Joe Garner will not play again this season after it emerged he suffered a fractured skull against Sheffield United last week.