The France number one was knocked out last week against Everton but, despite a furore, Villas-Boas said he was in contention for the Europa Cup clash on Thursday, instead Brad Friedel took the gloves.
Lloris is likely to return along with the likes of Andros Townsend and Roberto Soldado for the clash with Newcastle.
Erik Lamela will be hoping to feature against the Magpies after scoring his first goal for the club on Thursday in the win over Sherriff Tiraspol and Aaron Lennon will also be hoping he can feature.
Defender Danny Rose (toe), midfielder Sandro (hamstring) and left-back Zeki Fryers (groin) are out.
Paris Saint-Germain are reportedly ready to launch a summer raid for Chelsea left-back Marcos Alonso.
Terriers midfielder Phillip Billing has spoken about the whirlwind nature of his move from Denmark to Huddersfield as a teenager.
Malcom has admitted the time is right for him to leave Bordeaux and is dreaming of a move to German giants Bayern Munich.