Villas-Boas must decide whether to stick with Hugo Lloris or recall Brad Friedel in goal and Emmanuel Adebayor could make his first league start of the season at his former club.
Mousa Dembele (hip), Scott Parker (Achilles), Benoit Assou-Ekotto and Younes Kaboul (both knee) are unavailable.
Darren Ferguson declared his delight at a 'big win' for Doncaster after they saw off Bradford 2-0.
Doncaster took a major step towards securing their Sky Bet League One survival by beating Bradford 2-0.
Southampton manager Mark Hughes was delighted to see his new side reach the FA Cup semi-finals but also warned that the Premier League remains a concern.
Borussia Dortmund winger Andre Schurrle was delighted with the team's hard-fought 1-0 Bundesliga victory over Hannover 96 on Sunday afternoon.