The Tottenham boss has no fresh injury or suspension concerns, although Jan Vertonghen will miss the next Champions League game after he was sent off in Wednesday’s 3-1 win over Borussia Dortmund.
Pochettino made three changes in midweek from last weekend’s superb victory at Everton, switching to a back four which included Serge Aurier at the expense of Kieran Trippier.
The Ivory Coast international could keep his place while fellow new signing Davinson Sanchez will only return if Pochettino reverts to a back three.
Mousa Dembele appears to be back in favour after dropping to the bench for the win at Goodison Park, which could see Moussa Sissoko remain as a substitute.
Erik Lamela is not yet ready to return after a long injury lay-off.
Grimsby are open to talking to Sol Campbell about their vacant managerial position - and the former England defender wants to make it happen.
Grimsby are open to talking to Sol Campbell about their vacant managerial position.