Heurelho Gomes and Jose Holebas have been struck down by illness and will not play, but it is hoped that second string keeper Costel Pantilimon will recover.
Brice Dja Djedje could make his debut off the bench after recovering from a foot injury and will be joined among the replacements by Ben Watson, who has been missing due to personal reasons.
Noordin Amrabat is out of the African Cup of Nations through injury, Juan Camilo Zuniga picked up a problem in the warm-up prior to facing Spurs and Valon Behrami was injured against Stoke.
Provisional squad: Pantilimon, Zuniga, Cathcart, Prodl, Britos, Watson, Dja Djedje, Kabasele, Kaboul, Mason, Capoue, Guedioura, Amrabat, Okaka, Doucoure, Kenedy, Ighalo, Sinclair, Deeney.
Wigan staged an impressive fightback to draw 2-2 with League One leaders Blackburn at Ewood Park.