The Airlie Birds ran in five tries at the KCOM, with half-back Albert Kelly grabbing a brace to help seal their fourth win from five matches in 2017 and maintain the pressure on leaders Castleford.
Having won the Challenge Cup and made the play-offs of the Super 8s last season, a Grand Final appearance is a realistic goal for the Humbersiders.
Next up is a trip to Wigan and Radford admitted after Friday's win that although he was pleased with his side's performance, he still feels they have room for improvement in defence.
"The start to the second half built the foundations for that win," Radford told Hull FC Live.
"We knew Widnes would come here scrapping for a win so to come away with the result is really pleasing.
"Everything we do is around our defence so to have the best record in the league is really pleasing. But we're going to have to be even better next week because Wigan are good coming forward."