Gale will be out for most of the remaining part of the Super League season following his surgery on Wednesday, and could even miss the Grand Final at Old Trafford should Castleford reach it.
It comes as a huge blow for the half-back, who has been instrumental in the Tigers' impressive season during which they won their maiden League Leaders' Shield.
However, Wane says Castleford are overplaying their injury woes and has argued that Shaun O’Loughlin is a bigger miss to Wigan than Gale will be to Cas.
"He's not as big a blow as us losing Lockers, I can assure you," he told Wigan Today.
"That's one player - try doing it with nine, 10, 11 players out, like we've had to. Cas have done well with injuries, no question about it."
"They’ve got one out now and it’s big news - just get on with it. I wish I’d only had one player out."