The Cherry and Whites begin their European campaign with a clash against the French outfit on Thursday, hoping to go one better than last season when they were runners-up after losing to Stade Francais in the final.
Ackermann admits the competition is new to him but he is looking forward to the tournament and hopes his side build on last weekend's win over Northampton in the Aviva Premiership.
He said on the Gloucester website: "I obviously don't know much about the competition, but I watched it last year with Gloucester going all the way to the final. I know we've got a good record in the competition. But I'm excited as it's bringing a new challenge and going to new places that you haven't seen.
"We will have a lot of good spirit and positive energy after Saturday, as well as confidence I hope. As I say, it's a new challenge for me personally as I haven't coached in France before, and we're also looking to change a few players but we'll go with a positive mindset."
Ackerman has made plenty of changes for the Pau tie, with just six keeping their places from the victory over Saints. Skipper Tom Savage, Jacob Rowan, Owen Williams, David Halaifonua, Billy Twelvetrees and Henry Purdy are all retained while flanker Jake Polledri makes his debut and Australia international prop James Hanson, who is on the bench, is in the squad for the first time.