The Scots headed into last weekend's Calcutta Cup clash at Twickenham with high hopes but were blown away by the Red Rose, who ran in seven tries on their way to a 61-21 Six Nations win.
Despite that disappointment, Scotland's wins over Ireland and Wales mean victory against the Azzurri would round off a decent tournament.
If results go their way, a victory could see them finish second in the standings to end coach Vern Cotter's reign on a high.
Wilson has shaken off a head knock to make the starting XV at Murrayfield and after their poor showing last time out, the 27-year-old has urged his troops to make sure they end with a bang.
"At the beginning of this campaign I said that to get three home wins would be a massive thing for us," said Wilson. "We're on track to get that and if we finish second then it will be a successful campaign because we will finish higher than we ever have.
"What happened last week was unacceptable in a Scotland shirt. We're excited to right the wrongs, go out and put in a good performance at home. We need to go out with all guns blazing - start well and carry it on for 80 minutes.
"Playing at home in front of a sold-out crowd, the first time we've sold out Italy, is testament to how well we are doing. People want to come and watch a good brand of rugby. Getting the win will put us up there in the table and it is a huge game all round."