Former Rosanero midfielder Corini is the third man to take charge at the Stadio Renzo Barbera this season, with Davide Ballardini having been sacked after just two games while De Zerbi was given his marching orders following the Coppa Italia penalty shoot-out defeat to Serie B side Spezia on Wednesday.
That loss extended Palermo's losing run to eight matches in all competitions while they have lost all seven of their home matches in Serie A this season, leaving them at the foot of the table.
Corini looks like he has a tough job on his hands, as he takes charge of his fifth different club, but he does have experience of surviving relegation against the odds after guiding Chievo to safety in 2013.
"I’m happy and excited, I’m aware that hard work is waiting for me but I’m used to carrying out such an arduous task,” said Corini, who made over 100 appearance for Palermo during his five years with the club as a player.
“I gladly accepted President Zamparini’s invitation for me to return to Palermo, but I still haven’t met him. With desire, commitment and strength, but above all togetherness, I’m convinced that we can stay up.”