Caldara has been in fine form for the Italian outfit this season and his impressive performances have helped the club climb to fifth in the table, just one point behind Roma in second.
The 22-year-old, who joined La Dea in 2013 as a youth player, has managed to break into the first team this term following two impressive loan spells at Trapani and Cesnea.
He has made seven league appearances, scoring three goals in the process, and the centre-back's stock is rising rapidly as a number of teams eye a January deal.
Manchester United, Arsenal and Chelsea are expected to lock horns in the next transfer window as the three English rivals looks to strengthen their defensive ranks.
Italian champions Juventus are also said to be showing a keen interest and it looks unlikely Atalanta will be able to keep hold of their promising defender.
No official amount has been placed on Caldara but, with his contract running until 2021, a sizeable bid is likely to be needed.