The midfielder was recovering from ruptured ligaments he suffered in October last year when he was struck down by the same injury in February.
Florenzi, 26, has battled his way back to full fitness and finally returned in the Giallorossi's 3-0 Serie A win against Verona on Saturday.
After providing an assist for Edin Dzeko and coming through the game unscathed, he said: "My focus was all on Verona, the emotion of coming back in a match situation and trying to do my best for the team.
"I wanted to make it look as if I just rested for 11 months! I ran a lot today and I’m glad you could tell. It has not been an easy time, as the second injury especially was a heavy blow, but it taught me a lot about sacrifice. It made me a stronger person."