Sixteenth-placed Il Grifone have won just once since December and last weekend's defeat to local rivals Sampdoria marked the first time in 57 years that they have lost both editions of the Derby della Lanterna in a single season.
The result sparked protests from their fans and the squad were swept away to a training camp near Milan in order to help keep them out of the firing line.
Saturday sees them take on the improving Rossoneri and Mandorlini, who took over the team from Ivan Juric last month, has called on his troops to prove their doubters wrong by producing a performance against Vincenzo Montella's men.
"We wanted to do more in the derby, that is clear, and a very different type of game," he told reporters. "Now we have to look forward and think positive, taking it one game at a time.
"We must react to get results even in difficult arenas, building on the progress we have made.
"It has been good for the players to spend more time together. The malcontent must become motivation for us to all give something more."