Manolas has starred in the Giallorossi defence this season but Roma could face a battle to keep hold of the Greece international when the transfer window reopens.
The defender is under contract until 2019 but it is thought a bid in the region of 35million euros could be enough to convince the Serie A giants to sell this summer.
Chelsea and Arsenal are believed to have failed with bids to land Manolas last summer and the Gunners have retained an interest, although it appears as if Chelsea are no longer keen.
The latest speculation suggests Liverpool are ready to make a move when the transfer window reopens as Jurgen Klopp is eager to bolster his options at centre-half.
Everton and Manchester United are also reported to have scouted the 25-year-old this season and it seems as if Roma could face a fight to keep hold of the Greek star.