The 51-year-old spent the majority of his playing career with the Blucerchiati, winning the Scudetto, four Coppa Italia and the Cup Winners' Cup during 15 years in Genoa.
He scored 158 goals from 566 appearances in all competitions before going on to manage the likes of Lazio, Inter and Manchester City.
Mancini's second spell with Inter ended by mutual consent last summer and he has been a keen observer of the Italian top flight this term.
Sampdoria are currently down in 15th spot but the Jesi-born tactician feels they are not as bad as the statistics suggest.
"Sampdoria, unfortunately, have had a bit of bad luck," he told Telegenova. "I’ve seen a few games and they deserved more points, the table is a bit of a liar. I think [Marco] Giampaolo is working well, and he should continue to do so because it'll pay off in the end."
And he left it open as to whether he will ever be seen in the Stadio Luigi Ferraris dug-out, adding: "Could I coach Sampdoria one day? It’s difficult to say what will happen one day."