The Owls' survival hopes have been dealt a major blow with confirmation Antonio has been ruled out for the rest of the season due to a groin injury sustained in Saturday's home defeat to Cardiff.
The winger, who has scored nine goals in 42 appearances for Wednesday this season, was stretchered off on Saturday after suffering the injury during an aerial challenge with Leon Barnett, and scans have confirmed he will play no further part this season.
Antonio, 22, who has registered nine assists this season, has been a regular for Dave Jones' side since making an initial loan move from Reading permanent in the summer of 2012.
Jones has until 5pm on Thursday when the loan deadline closes to find a replacement for the player.
The Wednesday boss will be hoping to bring Connor Wickham back to Yorkshire. The Sunderland teenager returned to his parent club last week after making five appearances for the Owls during a month-long spell with the club.