Striker Charlie Austin is making good progress and is close to resuming training after a shoulder injury and could soon be joined by defender Jeremy Pied as he continues to work his way back after a knee operation.
Defender Martin Caceres will be hoping to feature following his arrival in February, however goalkeeper Alex McCarthy, full-back Matt Targett and centre-half Virgil van Dijk are still out injured.
It means Puel could opt to select the same side that won 4-3 at Watford on March 4.
The Saints head into the game looking for a second straight win at White Hart Lane after triumphing 2-1 in May.
Provisional squad: Forster, Taylor, Bertrand, Yoshida, Caceres, Gardos, Cedric, Hesketh, Romeu, Clasie, Ward-Prowse, Isgrove, Tadic, Redmond, Boufal, Lewis, Stephens, Hojbjerg, McQueen, Sims, Rodriguez, Gabbiadini, Long.