The England Under-21 captain has stepped up to the senior squad for the first time after impressing this season and will be reunited with Gareth Southgate having worked with him as an U21 international.
He is hoping to feature in Wednesday's friendly in Germany and then possibly win a place in the side for Sunday's World Cup qualifier against Lithuania at Wembley.
Ward-Prowse said: "It's obviously an incredibly proud feeling for me. It's always been a life-long ambition and a career ambition to reach the senior squad.
"I think it's every young player's dream to play for England and to be given that opportunity and chance to represent your country and do everyone proud is a great honour.
"Should the chance come this week, I'll be ready to take it. I can't wait to draw every ounce of knowledge from other players who have been in the group before this week, to help me as a player as well."
Saints team-mate Nathan Redmond, another yet to make his senior debut, has also moved up to the senior side.
"I couldn't stop my smile (when he was called up), it was one of those moments where I couldn't wait to call my mum and immediate family," said the forward. "It just seemed a bit surreal, for the rest of the day, and it was a dream come true.
"When I phoned my mum she started screaming down the phone, she was like 'finally you did it'. Being in the Premier League for the last couple of seasons, it's been one of my goals to play consistently and get into this senior side.
"She was ecstatic for me but at the same time was saying 'it starts now, you've worked hard to get here and now you have to work hard to stay'.
"To see so many faces I have seen in the under-21s is a good feeling. I'm here on merit, as the manager has said, and hopefully I can show that."