Manager Pochettino could again make 11 changes for Wednesday's fourth-round clash at the Stadium of Light, having done exactly that for the 2-0 win against Bristol City in the third round.
That side still included five senior internationals, though, and highlights the strength in depth at the Argentinian's disposal.
Cork and Ramirez are among those expected to start, while Kelvin Davis will deputise in goal and Jos Hooiveld and Maya Yoshida will also hope to be involved along with Tadanari Lee and Steve Davis.
Guly do Prado, who did play in the last round, remains sidelined with a knee injury so he misses out.
Southampton last week