The 30-year-old suffered ligament damage in his back that ruled him out of last week’s 2-2 draw with his former club Manchester United, and he will not be risked for the trip to take on Rafa Benitez’s men.
Hughes will also consider the fact that the Potters face Chelsea next weekend without Kurt Zouma, who is ineligible against his parent club as he is on loan at Stoke.
"It's touch and go," Hughes said. "In fairness, the last few weeks prior to the injury during the international week we tried to manage Ryan's workload and then he came back and got injured in training."
"We will check him again today and he may come in with a really positive attitude towards the game at the weekend and then I have a decision, but as things stand, it's unlikely."
Elsewhere, Geoff Cameron is the only other short-term injury worry after he picked up a hamstring problem in the first half of last week’s game with United.