The Black Cats currently sit bottom of the table and head into the visit of the Clarets on a run of three straight defeats.
With time running out in their survival bid, every point looks set to count but they have made a habit of winning crucial games at home.
They will also be buoyed by the knowledge that Burnley are yet to win away from Turf Moor this season and have not won any of their last six in all competitions.
Ndong admits that three points on Saturday is a must for David Moyes' men and believes a positive result could prove crucial to their hopes of avoiding the drop.
He told the club's official website: "It's one of the most important games of our season. It's crucial because it's one of the games that can directly affect our season, so we need to win because the earlier we pick up points the better.
"We want to stay in the Premier League and by beating Burnley we can edge closer to that goal."