The Swans lie just one place and one point behind the Magpies in 11th spot in the Barclays Premier League table, after coming from behind to draw at Southampton last weekend.
Newcastle, meanwhile, slumped to a 1-0 home defeat against West Ham, and manager Alan Pardew has stressed the importance of picking up three points against their Welsh visitors.
Laudrup is confident his side can continue a good recent run of just one defeat in six games in all competitions at the Sports Direct Arena, but knows they will need to perform well against a Newcastle side brimming with attacking potential.
He said: "If we are at our best we could get three points or just one, but there are loads of factors that can effect this game.
"If they are at their best they are a team who can cause us loads of problems, they have some physical players but also the likes of Yohan Cabaye and Ben Arfa, who have lots of quality, and Demba Ba who is in a great moment in front of goal.
"At our best we can get something from this game but if they are at their best they can make us suffer."