The Argentinean had dropped to a world ranking of 1,145 after suffering a number of wrist injuries in recent years.
Del Potro, the 2009 US Open champion, is now back in the world top 50 following a strong end to the campaign and he is now expected to continue his rise in 2017.
After winning a silver medal at the Rio Olympics, Del Potro then guided Argentina to its first ever Davis Cup final win on Sunday.
He will now take a few weeks off before playing in the ASB Classic in January and director Karl Budge admits his participation is a huge boost.
"His year has been incredible, especially to beat two current world number ones," he told reporters.
"It's a hell of a comeback. He is the player that none of the big four want to draw in Melbourne.
"The fact that he is unseeded and can land anywhere on the draw will be the talking point to see who he plays on Monday or Tuesday."