Konta enjoyed a strong 2016 campaign as she won her first WTA title in Stanford in June after beating seven-time Grand Slam champion Venus Williams.
After being ranked at 147th in the world in June 2015, Konta ended the year as the world number 10 and the dramatic rise saw her win the Women's Tennis Association's most improved player award for 2016.
The 25-year-old is expected to kick on even further in 2017 but she has now confirmed Carril will not remain on board.
She said: "After two-and-a-half successful years working together we have mutually agreed to explore new options.
"Once things are confirmed we will share the new set-up."