Pedro's sublime strike cancelled out Christian Eriksen's superb opener and Victor Moses struck what proved to be the winner for Chelsea, who returned to the top of the table.
Spurs on the other hand now have just one win in 10 games in all competitions, but Pochettino insists he is not unduly concerned.
"No worry, no concern," he said. "I think after that game you only feel proud. If you analyse the whole game, I think we deserve more, minimum the draw.
"I think we were better, but we lost. They were clinical in front of goal and we weren't."
Pochettino's changes for the midweek loss at Monaco were questioned as Spurs exited the Champions League. But he defended them even though they did not pay off when Jan Vertonghen, Kyle Walker and Eriksen returned to the side.
"We are competing in Champions League and Premier League and to be competitive you need sometimes to give rest to some players," he said.
"Regret never. We are professional and we try to make the best decisions for the team."