Mauricio Pochettino left Jan Vertonghen, Kyle Walker and Christian Eriksen on the bench in the Champions league in midweek with Chelsea in mind.
Vertonghen's omission was the most surprising, given he was not carrying an injury, and it is possible Pochettino was preserving the Belgian, who will be the only available option at left-back this weekend.
Danny Rose, who started in France, will be serving a domestic suspension and Ben Davies is out with an ankle problem.
"It is a question for the manager," Lloris said. "We know we have a good squad and sometimes it can happen that the manager rotates, but that kind of thing shouldn't affect the team because we have enough quality in the squad."