Davies was benched for Saturday's goalless draw with Burnley at Wembley after sustaining an ankle injury in Tottenham's 3-1 Champions League victory over Borussia Dortmund on Wednesday.
Pochettino opted to deploy Heung-Min Son in the left wing-back role but he wasn't as effective as Davies has been while deputising for Danny Rose.
The Spurs boss insists he stands by his decision to rotate his starting eleven and feels it will be key to ensuring they can compete on all fronts this term.
Pochettino said: "He got a big knock on his ankle against Borussia Dortmund.
"For different reasons we needed to rotate because we have a lot of games ahead.
"But I think one player is not the key to winning or losing. When you have 25 players you can use everyone."