Spurs will look to challenge for the Premier League title for a third year running this term, but they will have to play their home games away from White Hart Lane.
The club are still in the process of building their new stadium and Pochettino's men will play the full season at Wembley.
Pochettino's side were forced to play nine games at the national stadium last season but they failed to impress and only won two of them matches.
Tottenham exited the Champions League at the group stages last year after playing at Wembley but Pochettino is feeling good as they look to win the league, which you can back using your free bet.
He told Sky Sports News HQ: "We are ready and we are excited. We will try to win the Premier League.
"It is another challenge to make Wembley our home, but we are very positive about next season.
"Sometimes last season it was an easy excuse - because it is Wembley and we cannot play the same way as we did at White Hart Lane. Now, everyone knows, we have to go to Wembley and play. No excuses. It is a massive change in our minds.
"Wembley is fantastic, and could be magic for us. That is the challenge for us."
Spurs have yet to make any new signings ahead of their first game of the campaign against Newcastle United but Pochettino has hinted at a few potential deals.
He added: "We have a very clear philosophy. It is so difficult when you have a good team and want to stick to this philosophy. We are working hard and I am sure we will add some players by the end of the transfer window."