Pochettino gave short shrift to Sissoko's comments following the defeat in Monaco that Tottenham would prefer to play Europa League games at White Hart Lane rather than Wembley.
The Argentinian has proven himself ruthless with players that fail to toe the line as the sales of Andros Townsend, Emmanuel Adebayor, Paulinho, Etienne Capoue and Younes Kaboul have shown in the past.
Pochettino suggested Sissoko is not fulfilling his potential.
"It is not frustrating for me. It is about football. We can see in football different things happen," Pochettino said.
"If you sign a player and you expect something, and you do not find what you expect and if another deserves to be involved, like (Georges-Kevin) Nkoudou or (Vincent) Janssen - why? Because we paid money we need to put the player to play?
"Of course he needs to work hard and show in the future he deserves to be involved in the team."