Zuniga dropped out of the starting lineup shortly before kick off against Tottenham on New Year’s Day after complaining of pain in his ankle.
Forward Amrabat had to leave the field with a leg injury in the defeat to Spurs at Vicarage Road and is not expected to recover in time.
Midfielder Ben Watson was granted permission to miss the last game due to personal reasons and is likely to be unavailable again.
Adrian Mariappa and Roberto Pereyra, Stefano Okaka, Daryl Janmaat, Valon Behrami and Isaac Success have all been ruled out with muscle injuries.
However, Walter Mazzarri will be able to welcome back defender Miguel Britos, who returns after serving a one-game suspension.