The Baggies will get their season underway on Saturday when Bournemouth travel to the Hawthorns before taking on the likes of Burnley, Stoke, Brighton and West Ham in the opening few weeks.
Pulis, who is embarking on his third season in charge of West Brom, insists every Premier League game provides difficulties but hopes they can begin on a positive note.
The 59-year-old has challenged his men to go into the games full throttle as they attempt to put some early points on the board.
Pulis said: "I've been in it for ten years and every time I've picked the fixtures up I've thought 'they are going to be tough games', irrespective of who you've got.
"There's not an easy game in the Premier League.
"If you go into any game not at full tilt, at West Bromwich Albion or any other team outside maybe the top six, then you'll come unstuck. Playing Bournemouth at home will be a really tough game.
"They’re all tough games.
"Every game we approach in the right manner and the right frame of mind and full throttle.
"We’ve had to do that to win games."