The Irishman, selected ahead of summer signing Razvan Rat, was part of a Hammers back four which kept a clean sheet in the 2-0 defeat of Cardiff City.
Now O'Brien is targeting a repeat showing of the win at St James' Park last term, when he set up the winner for former Newcastle captain Kevin Nolan.
"I was delighted to get the nod (against Cardiff)," O'Brien told West Ham TV. "Roland is a smashing player and George McCartney is on his way back as well, so hopefully I can stay there or whoever comes in can play well.
"It (Newcastle) is a very hard place to go, but we'd take what happened last season and if Kev could score again that would be great.
"We're going up there setting off to keep a clean sheet and we'll see how we go from there.
"That will be aim and hopefully we can defend the way we did against Cardiff and get a result."