Bilic plans to make changes for the EFL Cup clash, with summer signings Sofiane Feghouli and Edimilson Fernandes among those set for a chance to start.
But the Croatian has made it clear he is desperate for the Hammers to get through to the semi-final stage.
"We are going to do everything we can to beat them," he said. "Man United are probably also going to change their team.
"What we expect is the same shape from them, same kind of football, just different names.
"When we say we are going to give a few players a chance it doesn't mean we are going just to play a game, and that we regret beating Chelsea in the last round.
"It's a quarter-final, which means if you win you are in semis and that's a big thing, and only a couple of games to final."
The sides drew 1-1 at Old Trafford in the Premier League on Sunday.