The midfielder struck with a little over 10 minutes to go at Upton Park to add to Matt Jarvis' first-half score and kill off any lingering chances of Wigan leaving east London with a positive result.
The defeat leaves the Latics in the Barclays Premier League relegation zone but moves West Ham back into the top half of the table.
Nolan, 30, had two chances in the first half to score the landmark goal but had to wait until late on after being set-up by close friend and former lodger Carroll.
"I'm absolutely delighted. To get to 42 points and to reach 100 goals too was nice," Nolan said.
"We have combined for quite a few goals - he keeps reminding me and saying that it's never the other way around. The big man's been fantastic since he's come back into the team.
"He's looking really sharp and fit - he had another couple of good chances on Saturday. We seem to get on really well on and off the pitch, we just click and that's helped us with our games."
Carroll has been in impressive form of late and West Ham manager Sam Allardyce remains hopeful he may be able to tie up a permanent deal for the Liverpool loanee in the summer.
Nolan also wants Carroll to stay and has urged his team-mates to finish the season strongly after all-but securing their top-flight status.
"I'm delighted that he's here and I'm hoping he will be for as long as I'm here," Nolan said.