The influential midfielder was on the bench for the victory over Bolton a fortnight ago having missed several weeks while on African Cup of Nations duty.
Despite having been left out at the Reebok Stadium Diame looks set to reclaim his place in the first team, with James McArthur potentially making way.
Striker Callum McManaman has recovered from a back problem while a number of players were able to overcome colds and viruses during the club's recent trip to Oman.
The only long-term absentee is still Chris Kirkland, who hasn't been in action since picking up a problem back in October.
Saturday's clash will see Charles N'Zogbia return to the DW Stadium after he left the club to join up with Aston Villa during the summer.