Latics boss Roberto Martinez made a host of changes for last weekend's FA Cup third round clash against Bournemouth but will recall his star men for the trip to Craven Cottage.
New signing Espinoza had to settle for a place on the bench but after a full week of training under his belt he could be in line to make his first start for the club.
The same applies to Angelo Henriquez, who came off the bench against the Cherries and played the second half.
Meanwhile Antolin Alcaraz is closing in on a return to action but Martinez does not want to rush him and it will be a couple of more weeks before he is ready to play.
"From a medical point of view, he is nearly, nearly there, and will probably come back into the equation over the next couple of games," Martinez revealed.
"He's back training with the group and he's slowly adapting to the workload. It's more a case of adaptation to work now rather than injury healing."
Wigan last week