Diame has missed the last two matches with a groin injury, but is back in training and now poised to play his part in the club's battle to beat the drop from the Barclays Premier League.
Ahead of games which see Wigan face Chelsea at Stamford Bridge on Saturday, host Manchester United on Wednesday and head to Arsenal five days later, 24-year-old Diame's presence could prove vital.
However, the flip side for Martinez is that striker Hugo Rodallega, sidelined for the last three matches with a knee injury, looks set to sit out the next three as well.
"We've really good news with Momo - he's trained the last two days with no reaction," said Martinez. "I consider him fully fit and I hope he will be available for the Easter period.
"The contrast is Hugo cannot make the squad for Saturday, so we will have to be a little more patient with him. It's not a big, long-term problem. He's in the last phase of his treatment, so hopefully over the next 10 days he will be fully fit."