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Arsenal proved their superiority over the rest of Europa League Group H as they ended the pool stages with a 6-0 win over BATE Borisov.
Everton gained their first Europa League win as a youthful side bowed out of the competition with an impressive display in Nicosia.
Bryan Cristante and Andreas Corneluis scored twice with Robin Gosens also on target as Atalanta thrashed Everton 5-1 at Goodison Park.
An Arsenal side that showed 11 changes to the team that beat Spurs on Saturday lost 1-0 to Koln in the Europa League.
Arsenal confirmed their place in the Europa League knockout stages with a frustrating goalless draw against Red Star Belgrade.
Everton are out of the Europa League after goals from Bertrand Traore, Houssem Aouar and Memphis Depay secured a 3-0 win for Lyon.
Bertrand Traore hit a late winner as Lyon beat Everton 2-1 at Goodison Park to pile more pressure on Toffees manager Ronald Koeman.
Olivier Giroud scored late on for Arsenal as the Premier League side downed 10-man Red Star Belgrade 1-0 in Serbia.
Everton will go in search of a first win in their Europa League group, when they welcome Lyon to Goodison Park on Thursday night.
Hector Yuste's late header snatched a 2-2 draw for Apollon Limassol after Nikola Vlasic looked to have sealed victory for Everton.