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Southampton will look to extend their impressive away record when they head to Crystal Palace on Tuesday.
A crucial relegation six-pointer takes place in the West Midlands on Tuesday night as Aston Villa take on Watford in the Premier League.
Everton will be missing forward Richarlison for the visit of Newcastle on Tuesday night as he continues to struggle with a knee injury.
Burnley will be without Ashley Barnes for their home game against Leicester after the attacker underwent hernia surgery.
A crucial relegation clash takes place at Carrow Road on Saturday as rock-bottom Norwich City go up against 19th-placed Bournemouth.
Liverpool have been boosted by the return of Joel Matip and Fabinho from injury ahead of Sunday's Premier League clash with bitter rivals Manchester United.
Brighton could welcome back Aaron Mooy when they host Aston Villa in the Premier League on Saturday.
Resurgent Southampton have no fresh injury concerns as they prepare to face Wolverhampton Wanderers on Saturday afternoon.
Manchester City have no fresh injury worries ahead of their clash with Crystal Palace at the Etihad on Saturday.
Newcastle United will be able to recall Allan Saint-Maximin for the visit of in-form Chelsea on Saturday.
Left-back Bukayo Saka is on standby to start against Sheffield United as Arsenal could be without injured Sead Kolasinac and banned Pierre-Emerick Aubameyang.
Watford could call on new boy Ignacio Pussetto as they look to continue their resurgence at home to Tottenham on Saturday.
Everton boss Carlo Ancelotti has confirmed defender Yerry Mina is a doubt for Saturday's Premier League clash away at West Ham United.
Manchester United will be without Ashley Young when they face Wolves in an FA Cup third-round replay on Wednesday.
Tottenham Hotspur boss Jose Mourinho has challenged his injury-ravaged side to deliver the goods when they host Middlesbrough on Tuesday in the FA Cup.
Newcastle boss Steve Bruce has vowed to name a strong side against Rochdale in Tuesday’s FA Cup third-round replay.
Andre Gomes and Alex Iwobi remain out for Everton as they prepare to host Brighton in the Premier League on Saturday.
Both Aston Villa and Manchester City need the points for contrasting reasons ahead of their meeting in Sunday's late game in the Premier League.
Southampton will have revenge on the agenda when they travel to Leicester City on Saturday afternoon.
Wolves will be looking to get their top-four hopes back on track when they play host to Newcastle in the Premier League on Saturday.
Cenk Tosun could go straight into the Crystal Palace starting XI for Saturday's Premier League clash with Arsenal at Selhurst Park.