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Manchester City continue their FA Cup defence against Championship outfit Fulham on Sunday and Pep Guardiola is expected to rest a few key men.
There will be a familiar face at the London Stadium on Saturday as West Brom boss Slaven Bilic faces former club West Ham in the fourth round of the FA Cup.
Steve Bruce says he will field a strong Newcastle side against League One Oxford in the FA Cup fourth round with loan signing Nabil Bentaleb set for his debut.
Chris Wilder has vowed to put out a "strong side" for Sheffield United's FA Cup fourth-round trip to face Championship side Millwall at The Den on Saturday.
Southampton coach Ralph Hasenhuttl has confirmed he will be without three first-team stars for Saturday's FA Cup clash with Tottenham.
Ole Gunnar Solskjaer could shake things up with his selection when his side travel to Tranmere in the fourth round of the FA Cup.
Hull City are battling a host of defensive injuries ahead of hosting Chelsea in Saturday's FA Cup fourth-round clash.
Wolves will be looking to derail Liverpool's relentless march towards the Premier League title when the two teams meet at Molineux on Thursday.
Watford will be hoping it is third time lucky when they visit League One Tranmere in their FA Cup third round replay on Thursday.
Tottenham have midfielder Tanguy Ndombele available after a hip injury, while Norwich defender Ben Godfrey is suspended for Wednesday's Premier League game.
Mason Greenwood looks set to start his fourth Premier League match when Manchester United host Burnley on Wednesday night.
Leicester look set to be boosted by the return of Wilfred Ndidi when they host West Ham in the Premier League on Wednesday evening.
John Stones is an injury doubt for Manchester City when they go to Sheffield United, who themselves are sweating over the fitness of forward David McGoldrick.
Bournemouth desperately need to pick up a win when they welcome Brighton to the Vitality Stadium on Tuesday.
Chelsea can do the double over Arsenal for the first time since 2015-16 when the London rivals meet for the 200th time across all competitions on Tuesday.
Southampton will look to extend their impressive away record when they head to Crystal Palace on Tuesday.
A crucial relegation six-pointer takes place in the West Midlands on Tuesday night as Aston Villa take on Watford in the Premier League.
Everton will be missing forward Richarlison for the visit of Newcastle on Tuesday night as he continues to struggle with a knee injury.
Burnley will be without Ashley Barnes for their home game against Leicester after the attacker underwent hernia surgery.
A crucial relegation clash takes place at Carrow Road on Saturday as rock-bottom Norwich City go up against 19th-placed Bournemouth.
Liverpool have been boosted by the return of Joel Matip and Fabinho from injury ahead of Sunday's Premier League clash with bitter rivals Manchester United.