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Tottenham's injury woes continue as Steven Bergwijn and Ben Davies are the latest to be ruled out of Tuesday's Champions League tie at RB Leipzig.
Jamie Vardy is set to return for Leicester City when Aston Villa visit and Wilfred Ndidi is also in line to start the match.
Manchester United's Harry Maguire is expected to be fit for Sunday’s derby, while Manchester City have concerns over Kevin De Bruyne.
Brighton have defender Shane Duffy available for Saturday's game with Wolves after he missed the defeat against Crystal Palace last weekend for family reasons.
Chelsea have a number of injury concerns to contend with ahead of Sunday's visit of Everton in the Premier League.
Sheffield United will look to complete the league double over Norwich for the first time since 1939 when they meet at Bramall Lane on Saturday.
Crystal Palace are without Cenk Tosun against Watford on Saturday after he returned to Everton due to a serious knee injury but Mamadou Sakho could return.
In-form Burnley will be looking to add to Tottenham's recent woes when they meet at Turf Moor in the Premier League on Saturday.
Arsenal will be without midfielder Lucas Torreira for Saturday’s clash with West Ham as Mikel Arteta’s side look to move towards the top four.
Liverpool remain without captain Jordan Henderson for the visit of strugglers Bournemouth in the early Premier League kick-off on Saturday.
Southampton and Newcastle are both looking to pull further clear of the bottom three when they meet at St Mary’s on Saturday.
Leicester are without injured striker Jamie Vardy and Birmingham are set to rest teen sensation Jude Bellingham for Wednesday's FA Cup fifth-round tie.
Manchester City make the trip to Sheffield Wednesday on Wednesday night as the teams prepare to battle it out for a place in the FA Cup quarter-finals.
Spurs and Norwich do battle on Wednesday evening at the Tottenham Hotspur Stadium for a place in the quarter-finals of the FA Cup.
Sheffield United boss Chris Wilder is not expected to make many changes for Tuesday's FA Cup fifth round tie at Reading but Lys Mousset is pushing for a recall.
Chelsea boss Frank Lampard could recall Kepa Arrizabalaga for Tuesday's FA Cup fifth-round tie as the injury-hit Blues prepare to take on Liverpool.
Newcastle will hand late fitness tests to a number of players ahead of Tuesday night's FA Cup fifth round clash against West Bromwich Albion.
Mikel Arteta's desire to win the FA Cup as Arsenal manager could see him name a strong line-up in Monday's fifth-round tie at Portsmouth.
The 60th edition of the EFL Cup final takes place at Wembley on Sunday afternoon as Aston Villa take on defending champions Manchester City.
Everton will look to make it back-to-back home victories over Manchester United when they meet in the Premier League on Sunday.
Harry Kane has stepped up his recovery from injury but Tottenham's home clash with Wolves on Sunday will come too soon for the England captain.