Paris Saint-Germain boss Thomas Tuchel says his side must play “very intelligently” to deal with Borussia Dortmund on Wednesday night.
Atletico Madrid boss Diego Simeone says Liverpool will know what to expect from his side as they seek to defend a 1-0 advantage at Anfield on Wednesday.
Liverpool's Virgil van Dijk is looking for inspiration from last season's semi-final comeback against Barcelona ahead of their clash with Atletico Madrid.
Tottenham head coach Jose Mourinho says his side are up against it in their bid to get back into the Champions League next season.
Manchester United created another bit of European history 12 months ago when they edged past Paris Saint-Germain in the last 16 of the Champions League.
UEFA president Aleksander Ceferin insists it would "not be a problem" if Pep Guardiola's Manchester City won the Champions League this season.
Europe's big leagues are entering the business end of the season and there are a number of unfashionable teams challenging for a place in the Champions League.
The Manchester City players will have left the Santiago Bernabeu on Wednesday night with their chests puffed out and their heads held high.
With the Champions League last-16 first-leg ties done and dusted, the battle to make the quarter-finals could not be tighter.
Pep Guardiola has full confidence in Manchester City as they take their battle against their Champions League expulsion to the Court of Arbitration for Sport.
Frank Lampard has challenged Chelsea's players to restore some European pride after a brutal lesson from Bayern Munich.
Manchester City midfielder Ilkay Gundogan is has enjoyed a trophy-laden career but is still seeking a Champions League winners medal.